With several air freight providers serving the region, the Roanoke Regional Airport makes shipping easy. The following companies provide air freight service through the Roanoke Regional Airport:
- Air Cargo Carriers
- American Airlines
- Delta Connection Carriers
- Federal Express
- Quest Diagnostics
- United Express
- UPS
In addition, Franklin County is located just one and a half hours from the new Fedex hub at Piedmont Triad International Airport in Greensboro, North Carolina.